森信 暁雄　教授

森信 暁雄　教授

  • 名前（ふりがな）：森信　暁雄　（もりのぶ あきお）
  • 所属：教授
  • 資格　リウマチ専門医、指導医、認定内科医、総合内科専門医

ひとこと

リウマチ・膠原病は臨床も研究も興味が尽きることのない分野です。

やる気のある若手医師の参加を期待しています。

略歴

1988年 京都大学医学部医学科卒業
1995年 京都大学大学院医学研究科　修了
1997年 神戸大学医学部 臨床検査医学講座　助手
2000年 米国国立衛生研究所（NIH）　研究員
2004年 神戸大学大学院医学系研究科　臨床病態免疫学講座　講師
2012年 神戸大学大学院医学研究科　内科学講座免疫内科学　准教授
2020年 京都大学大学院医学研究科　内科学講座臨床免疫学　教授

学会活動

日本内科学会認定内科医　認定総合内科専門医　近畿支部評議員

日本リウマチ学会認定専門医　リウマチ指導医　評議員　近畿支部運営委員

日本臨床検査医学会臨床検査専門医

日本臨床免疫学会　免疫療法専門医　評議員

日本再生・炎症学会　評議員

等

研究テーマ

リウマチ・膠原病の病態解明

主要業績

  1. Morinobu A. JAK inhibitors for the treatment of rheumatoid arthritis. Immunol Med. 2020 Jun 5:1-8. 総説
  2. Takahashi S, Saegusa J, Onishi A, Morinobu A. Biomarkers identified by serum metabolomic analysis to predict biologic treatment response in rheumatoid arthritis patients. Rheumatology (Oxford). 2019 May 29
  3. Ueda Y, Saegusa J, Okano T, Sendo S, Yamada H, Nishimura K, Morinobu A. Additive effects of inhibiting both mTOR and glutamine metabolism on the arthritis in SKG mice.Sci Rep. 2019 Apr 23;9(1):6374.
  4. Sendo S, Saegusa J, Okano T, Takahashi S, Akashi K, Morinobu A. CD11b+ Gr1dim Tolerogenic Dendritic Cell-like Cells are Expanded in Interstitial Lung Disease in SKG Mice. Arthritis Rheumatol. 2017;69(12):2314-2327
  5. Takahashi S, Saegusa J, Sendo S, Okano T, Akashi K, Irino Y, Morinobu A. Glutaminase 1 plays a key role in the cell growth of fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Res Ther. 2017;19:76:1-11
  6. Okano T, Saegusa J, Nishimura K, Takahashi S, Sendo S, Ueda Y, Morinobu A. 3-bromopyruvate ameliorate autoimmune arthritis by modulating Th17/Treg cell differentiation and suppressing dendritic cell activation. Sci. Rep. 2017;7:42412:1-10
  7. Morinobu A, Tanaka S, Nishimura K, Takahashi S, Kageyama G, Miura Y, Kurosaka M, Saegusa J, Kumagai S.　Expression and Functions of Immediate Early Response Gene X-1 (IEX-1) in Rheumatoid Arthritis Synovial Fibroblasts.　PLoS One. 11(10):e0164350. 2016
  8. Nishimura K, Saegusa J, Matsuki F, Akashi K, Kageyama G, Morinobu A. Tofacitinib Facilitates the Expansion of Myeloid-Derived Suppressor Cells and Ameliorates Arthritis in SKG Mice. Arthritis Rheumatol. 2015;67(4):893-902
  9. Misaki K, Morinobu A, Saegusa J, Kasagi S, Fujita M, Miyamoto Y, Matsuki F, Kumagai S. Histone deacetylase inhibition alters dendritic cells to assume a tolerogenic phenotype and ameliorates arthritis in SKG mice. Arthritis Res Ther. 2011;13(3):R77:1-11
  10. Morinobu A, Tsuji G, Kasagi S, Saegusa J, Hayashi H, Nakazawa T, Kogata Y, Misaki K, Nishimura K, Sendo S, Miura N, Kawano S, Kumagai S.　 Role of imaging studies in the diagnosis and evaluation of giant cell arteritis in Japanese: report of eight cases.　　Mod Rheumatol. 21(4):391-6. 2011
  11. Akio Morinobu, Wang Biao, Shino Tanaka, Marika Horiuchi, Liu Jun, Goh Tsuji, Yoshitada Sakai, Masahiro Kurosaka, Shunichi Kumagai (-)-Epigallocatechin-3 -Galate suppresses osteoclast differentiation and ameliorates experimental arthritis in mice.  Arhtritis Rheum 58(7):2012-8. 2008
  12. Morinobu A, Wang B, Liu J, Yoshiya S, Kurosaka K, and Kumagai S Trichostatin A co-operates with Fas-mediated signal to induce apoptosis in rheumatoid arthritis synovial fibroblasts. J Rheumatol. 33(6):1052-60. 2006
  13. Morinobu A, Kanno Y, O’Shea JJ. Discrete roles for histone acetylation in human T helper 1 cell-specific gene expression. J Biol Chem 279(39):40640-6. 2004
  14. Nguyen KB, Watford WT, Salomon R, Hofmann SR, Pien GC, Morinobu A, Gadina M, O’Shea JJ, Biron CA. Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection. Science 2002;297(5589):2063-6
  15. Morinobu A, Gadina M, Strober W, Visconti R, Fornace A, Montagna C, Feldman GM, Nishikomori R, O’Shea JJ. STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation. Proc Natl Acad Sci U S A 99(19):12281-6. 2002
  16. Morinobu A, Wang Z, Kumagai S. Bucillamine suppresses human Th1 cell development by a hydrogen peroxide-independent mechanism. J Rheumatol 27(4):851-8. 2000
  17. Morinobu A, Kanagawa S, Koshiba M, Sugai S, Kumagai S. Association of the glutathione S-transferase M1 homozygous null genotype with susceptibility to Sjogren’s syndrome in Japanese individuals. Arthritis Rheum 42(12):2612-5. 1999
  18. Morinobu A, Kumagai S, Yanagida H, Ota H, Ishida H, Matsui M, Yodoi J, Nakao K. IL-10 suppresses cell surface CD23/Fc epsilon RII expression, not by enhancing soluble CD23 release, but by reducing CD23 mRNA expression in human monocytes. J Clin Immunol 16(6):326-33. 1996
  19. Akio Morinobu, Elaine Remmers, Daniel Kastner, and John J. O’Shea. ‘Principles and techniques in molecular biology’. 85-98 Rheumatology (3rd edition) edited by Hochberg MC, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH. 2004　分担執筆

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