三森 経世　名誉教授

三森 経世　名誉教授

三森経世
  • 名前（ふりがな）：三森　経世　（みもり つねよ）
  • 所属：名誉教授
  • 出身：福島県

研究主題

  • 膠原病・リウマチ性疾患の診断と治療
  • 膠原病における自己抗体の臨床的および病因的意義、産生機序

略歴

昭和53年 慶應義塾大学医学部卒業
昭和57年 慶應義塾大学大学院医学研究科修了
昭和57年-平成06年 慶應義塾大学医学部内科助手
昭和57年-60年 Yale大学Postdoctoral Associate
平成06年-12年 慶應義塾大学医学部内科講師
平成12年-31年

京都大学大学院医学研究科臨床免疫学　教授
京都大学医学部附属病院免疫・膠原病内科　
診療科長
令和1年-現在

京都大学大学院医学研究科臨床免疫学　名誉教授

医仁会武田総合病院　院長

代表的な業績

  1. Mimori T, Akizuki M, Yamagata H, Inada S, Yoshida S, Homma M: Characterization of a high molecular weight acidicnuclear protein recognized by autoantibodies in sera from patients with polymyositis-scleroderma overlap.J Clin Invest 68(9): 611-620, 1981
  2. Mimori T, Hinterberger M, Pettersson I, Steitz JA: Autoantibodies to the U2 small nuclear ribonucleoprotein in a patient with scleroderma-polymyositis overlap syndrome. J Biol Chem 259: 560-565, 1984
  3. Mimori T, Hardin JA, Steitz JA: Characterization of the DNA-binding protein antigen Ku recognized by autoantibodies from patients with rheumatic disorders. J Biol Chem 261(5):2274-2278, 1986
  4. Mimori T, Hardin JA: Mechanism of interaction between Ku protein and DNA. J Biol Chem 261(22):10375-10379, 1986
  5. Mimori T: Scleroderma-polymyositis overlap syndrome. Clinical and serologic aspects. Int J Dermatol 26:419-425, 1987
  6. Okada N, Mimori T, Mukai R, Kashiwagi H, Hardin JA: Characterization of human autoantibodies that selectively precipitate the 7SL-RNA component of the signal recognition particle. J Immunol 138(10):3219-3233, 1987
  7. Craft JE, Mimori T, Olsen TL, Hardin JA: The U2 small nuclear ribonucleoprotein particle as an autoantigen: Analysis with sera from patients with overlap syndromes. J Clin Invest 81:1716-1724, 1988
  8. Ohosone Y, Mimori T, Griffith A, Akizuki M, Homma M, Craft J, Hardin JA: Molecular cloning of cDNA encoding Sm autoantigen: Derivation of a cDNA for a B polypeptide of the U series of small nuclear ribonucleoprotein particles. Proc Natl Acad Sci USA 86:4294-4253, 1989
  9. Mimori T, Ohosone Y, Hama N, Suwa A, Akizuki M, Homma M, Griffith A, Hardin JA: Isolation and characterization of cDNA encoding the 80-kDa subunit protein of the human autoantigen Ku (p70/p80) recognized by autoantibodies from patients with scleroderma-polymyositis overlap syndrome. Proc Natl Acad Sci USA, 87(5):1777-1781, 1990
  10. Hirakata M, Mimori T, Akizuki M, Hama N, Satoh M, Ohosone Y, Okano Y, Homma M: Autoantibodies reactive with small nuclear and cytoplasmic ribonucleoproteins in Japanese patients with inflammatory muscle disease. Arthritis Rheum 35(4):449-456, 1992
  11. Ohosone Y, Mimori T, Fujii T, Akizuki M, Matsuoka Y, Irimajiri S, Hardin JA, Craft J, Homma M: Autoantigenic epitopes of theB polypeptide of Sm small nuclear RNP particles: Identification of regions accessible only within the U1 small nuclear RNP. Arthritis Rheum 35(8):960-966, 1992
  12. Fujii T, Mimori T, Hama N, Suwa A, Akizuki M, Tojo T, Homma M: Characterization of autoantibodies that react U4/U6 small nuclear ribonucleoprotein in serum from a patient with primary Sjogren’s syndrome. J Biol Chem 267(23):16412-16416, 1992
  13. Mimori T, Suganuma K, Tanami Y, Nojima T, Matsumura M, Fujii T, Yoshizawa T, Suzuki K, Akizuki M: Autoantibodies to human calpastatin (endogenous inhibitor for calcium-dependent neutral protease, calpain) in systemic rheumatic diseases.Proc Natl Acd Sci USA 93(16):7267-7271, 1995
  14. Matsumura M, Ohosone Y, Miyachi K, Akizuki M, Matsuoka Y, Irimajiri S, Shimizu M, Mimori T: Novel autoantibodies directed against the common tertiary configuration of transfer RNAs in a patient with interstitial lung disease. Arthritis Rheum 39(8):1308-1312, 1996
  15. Fujii T, Mimori M, Akizuki M: Detection of autoantibodies to nuclear transcription factor NOR90/hUBF in sera of patients with rheumatic diseases by recombinant autoantigen-based assays. Arthritis Rheum 39(8):1313-1318, 1996
  16. Mimori T: Update on structures targeted by the immune system in myositis. Current Opinion in Rheumatol 8(6):521-527, 1996
  17. Ohosone Y, Matsumura M, Chiba J, Nagaoka S, Matsuoka Y, Irimajiri S, Mimori T: Anti-transfer RNA antibodies in two patients with pulmonary fibrosis, Raynaud’s phenomenon and polyarthritis. Clin Rheumatol 17:144-147, 1998
  18. Ohosone Y, Ishida M, Takahashi Y, Matsumura M, Hirakata M, Kawahara Y, Nishikawa T, Mimori T: Spectrum and clinical significance of autoantibodies against transfer RNA. Arthritis Rheum 41(9):1625-1631, 1998
  19. Mimori T: Autoantibodies in connective tissue diseases. Intern Med 38(7):523-532, 1999
  20. Kanazawa Y, Kaneshiro Y, Sawa M, Yasuoka H, Nojima T, Ohosone Y, Mimori T: Domain reactivity of autoantibodiesto calpastatin in patients with systemic rheumatic diseases.Mod Rheumatol 10(1):38-44,2000

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