大村 浩一郎 准教授

大村 浩一郎 特命准教授

  • 大村 浩一郎 (おおむら こういちろう)
  • 特命准教授
  • 広島県呉市出身
  • 好きなもの:温泉
  • 資格:

    日本リウマチ学会 リウマチ専門医・指導医、評議員、日本内科学会 認定内科医、日本免疫学会 評議員、日本炎症再生医学会 評議員、日本臨床免疫学会 評議員、日本温泉気候物理医学会 評議員、温泉療法医

研究主題

  • 膠原病のゲノム解析。SLEコホート研究。

受賞歴

平成13年 上原記念生命科学財団 海外留学助成金受賞 上原記念生命科学財団
平成14年 Arthritis National Research Foundation Fellowship Grant受賞 Arthritis National Research Foundation
平成17年 “5th Federation of Clinical Immunology Societies Meeting travel award

ひとこと

丁寧な診療を心掛けています

略歴

平成 2年3月 北海道大学医学部 卒業
平成 2年 – 平成 5年 天理よろづ相談所病院レジデント勤務
平成 5年 – 平成 11年 京都大学医学部附属病院 第二内科にて臨床、研究に従事
平成12年1月 医学博士号(京都大学)取得
平成12年 − 平成16年 米国ハーバード大学(ジョスリン糖尿病センター)へ留学
平成16年 − 平成18年 道後温泉病院リウマチセンター勤務
平成18年 − 平成23年 京都大学医学部附属病院 免疫・膠原病内科 助教
平成23年 − 平成26年 京都大学医学部附属病院 免疫・膠原病内科 講師
平成26年6月− 京都大学医学部附属病院 免疫・膠原病内科 准教授
令和2年10月−

京都大学医学部附属病院 免疫・膠原病内科 特命准教授

神戸市立医療センター中央市民病院 臨床免疫研究部 部長

代表的な業績

  1. Ohmura K. Which is the best SLE activity index for clinical trials? Mod Rheumatol. in press.
  2. Akizuki S., et al., PLD4 is a genetic determinant to systemic lupus erythematosus and involved in murine autoimmune-phenotypes. Ann Rheum Dis 2019, 78: 509
  3. Hiwa R, et al., Myeloperoxidase/HLA class II complexes recognized by autoantibodies in microscopic polyangiitis. Arthritis Rheumatol. 2017; 69: 2069.
  1. H. Kawamoto, K. Ohmura and Y. Katsura.. Direct evidence for the commitment of hemato-poietic stem cell to T, B and myeloid lineages in murine fetal liver. Int. Immunol. 1997; 9: 1011-1019.
  2. H. Kawamoto, K. Ohmura and Y. Katsura. Presence of progenitors restricted T, B, or myeloid lineage, but absent of multipotent stem cells, in the murine fetal thymus. J. Immunol. 1998; 161: 3799-3802.
  3. H. Kawamoto, K. Ohmura, S. Fujimoto and Y. Katsura. Emergence of T cell progenitors without B cell or myeloid differentiation potential at the earliest stage of hematopoiesis in the murine fetal liver. J. Immunol. 1999; 162: 2725-2731.
  4. K. Ohmura, H. Kawamoto, S. Fujimoto, S. Ozaki, K. Nakao and Y. Katsura. Emergence of T, B and myeloid lineage committed as well as multipotent hematopoietic progenitors in the AGM region of day 10 fetuses of the mouse. J. Immunol. 1999; 163: 4788-4795.
  5. H. Kawamoto, T. Ikawa, K. Ohmura, S. Fujimoto, and Y. Katsura. T cell progenitors emerge earlier than B cell progenitors in the murine fetal liver. Immunity 2000; 12: 441-450.
  6. K. Ohmura, H. Kawamoto, M. Lu, T. Ikawa, S. Ozaki, K. Nakao, and Y. Katsura. Immature multipotent hematopoietic progenitors lacking bone-marrow repopulating activity in the aorta-gonad-mesonephros region of murine day 10 fetuses. J. Immunol. 2001; 166:3290-3296
  7. H. Ji, D. Gauguier, K. Ohmura, A. Gonzalez, V. Duchatelle, P. Danoy, H. Garchon, C. Degott, M. Lathrop, C. Benoist, D. Mathis. Genetic influences on the end-stage effector phase of arthritis. Genetic influences on the end-stage effector phase of arthritis. J. Exp. Med. 2001; 194: 321-330.
  8. H. Ji, K. Ohmura, U. Mahmood, D. Lee, F. M.A. Hofhuis, S. Boackle, M. Holers, M.Walport, C. Gerard, A. Ezekowitz, M. C. Carroll, M. Brenner, R Weissleder, J. S. Verbeek, C. Benoist, D. Mathis. Arthritis critically dependent on innate immune system players. Immunity. 2002; 16: 157-68.
  9. H. Ji, A. Pettit. K. Ohmura, A. Ortiz-Lopez, V. Duchatelle, C. Degott, E. Gravallese, D. Mathis, C. Benoist. Critical roles for interleukin-1 and tumor necrosis factor-a in antibody-induced arthritis. J. Exp. Med. 2002; 196: 77-85.
  10. H. Kawamoto, K. Ohmura, S. Fujimoto, M. Lu, T. Ikawa, Y. Katsura. Extensive proliferation of T cell lineage-restricted progenitors in the thymus: an essential process for clonal expression of diverse T cell receptor beta chains. Eur. J. Immunol. 2003; 33: 606-615
  11. HQ. Shen, M. Lu, T. Ikawa, K. Masuda, K. Ohmura, N. Minato, Y. Katsura, H. Kawamoto. T/NK bipotent progenitors in the thymus retain the potential to generate dendritic cells. J. Immunol. 2003; 171: 3401-3406.
  12. K. Ohmura, LT. Nguyen, RM. Locksley, D. Mathis, C. Benoist. Interleukin-4 can be a key positive regulator of inflammatory arthritis. Arthritis Rheum. 2005; 52: 1866-1875.
  13. K. Ohmura, A. Johnsen, A. Ortiz-Lopez, A. Desany Johnsen, M. Roy, W. Besse, J. Rogus, M. Bogue, A. Puech, M. Lathrop, D. Mathis and C. Benoist. Variation in IL-1beta gene expression is a major determinant of genetic differences in arthritis aggressivity in mice. Proc Natl Acad Sci USA., 2005; 102: 12489-12494.
  14. Y. Ito, T. Usui, S. Kobayashi, M. Iguchi-Hashimoto, H. Yoshitomi, T. Nakamura, M. Shimizu, D. Kawabata, N. Yukawa, M. Hashimoto, N. Sakaguchi, S. Sakaguchi, H. Yoshifuji, T. Nojima, K. Ohmura, T. Fujii, T. Mimori. g/d T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis. Arthritis Rheum. 2009; 60: 2294-2303.
  15. R. Nakashima, Y. Imura, S. Kobayashi, N. Yukawa, H. Yoshifuji, T. Nojima, D. Kawabata, K. Ohmura, T. Usui, T. Fujii, K. Okawa, T. Mimori. The RIG-I-like receptor IFIH1/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibody. Rheumatology (Oxford). 2010 Mar;49: 433-40.
  16. Y. Ishikawa, N. Yukawa, K. Ohmura, Y. Hosono, Y. Imura, D. Kawabata, T. Nojima, T. Fujii, T. Usui, T. Mimori. Etanercept-induced anti-Jo-1-antibody-positive polymyositis in a patient with rheumatoid arthritis: a case report and review of the literature. Clin Rheumatol. 2010 May;29(5):563-6.
  17. H. Yamaguchi, T. Fujimoto, S. Nakamura, K. Ohmura, T. Mimori, F. Matsuda, S. Nagata. Aberrant splicing of the milk fat globule-EGF factor 8 (MFG-E8) gene in human systemic lupus erythematosus. Eur J Immunol. 2010;.40: 1-8
  18. T. Fujimura, N. Yukawa, R. Nakashima, Y. Imura, D. Kawabata, T. Nojima, K. Ohmura, T. Fujii, T Usui, T Mimori. Periodic fever and erythema nodosum associated with MDS with trisomy 8: report of two cases and review of the literature. Mod Rheumatol. 2010 Aug;20(4):413-9.
  19. T. Yokoyama, T. Usui, K. Kiyama, R. Nakashima, N. Yukawa, D. Kawabata, T. Nojima, K. Ohmura, T. Fujii, T. Mimori. Two cases of late-onset drug-induced lupus erythematosus caused by ticlopidine in elderly men. Mod Rheumatol. 2010 Aug;20(4):405-9.
  20. Y. Kochi, Y. Okada, A. Suzuki, K. Ikari, C. Terao, A. Takahashi, K. Yamazaki, N. Hosono, K. Myouzen, T. Tsunoda, N. Kamatani, T. Furuichi, S. Ikegawa, K. Ohmura, T. Mimori, F. Matsuda, T. Iwamoto, S. Momohara, H. Yamanaka, R. Yamada, M. Kubo, Y. Nakamura, K. Yamamoto. A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility. Nat Genet. 2010 May; 42(6): 515-9
  21. Sato T, Fujii T, Yokoyama T, Fujita Y, Imura Y, Yukawa N, Kawabata D, Nojima T, Ohmura K, Usui T, Mimori T. Anti-U1 RNP antibodies in cerebrospinal fluid are associated with central neuropsychiatric manifestations in systemic lupus erythematosus and mixed connective tissue disease. Arthritis Rheum. 2010 Dec; 62(12):3730-40
  22. K. Ohmura (corresponding author), C. Terao, E. Maruya, M. Katayama, K. Matoba, K. Shimada, A. Murasawa, S. Honjo, K. Takasugi, S. Tohma, K. Matsuo, K. Tajima, N. Yukawa, D. Kawabata, T. Nojima, T. Fujii, R. Yamada, H. Saji, F. Matsuda, T. Mimori. Anti-citrullinated peptide antibody-negative RA is a genetically distinct subset: a definitive study using only bone-erosive ACPA-negative rheumatoid arthritis. Rheumatology (Oxford) 2010; 49: 2298-304.
  23. Y. Ishikawa Y, Yukawa, D. Kawabata, K. Ohmura, T. Fujii, T. Usui, T. Mimori. A case of antisynthetase syndrome in a rheumatoid arthritis patient with anti-PL12 antibody following treatment with etanercept. Clin Rheumatol. 2011; 30: 429-32
  24. N. Takeda, T. Nojima, C. Terao, N. Yukawa, D. Kawabata, K. Ohmura, T. Usui, T. Fujii, Y. Ito, Y. Inuma, T. Mimori: Interferon-g release assay for diagnosing Mycobacterium tuberculosis disease in patients with systemic lupus erythematosus. Lupus 2011; 20:792-800.
  25. ○ Terao C, Yamada R, Ohmura K, Takahashi M, Kawaguchi T, Kochi Y; Human Disease Genomics Working Group; RA Clinical and Genetic Study Consortium, Okada Y, Nakamura Y, Yamamoto K, Melchers I, Lathrop M, Mimori T, Matsuda F. The human AIRE gene at chromosome 21q22 is a genetic determinant for the predisposition to rheumatoid arthritis in Japanese population. Hum Mol Genet. 2011; 20:2680-5
  26. Meziani R, Yamada R, Takahashi M, Ohigashi K, Morinobu A, Terao C, Hiratani H, Ohmura K, Yamaguchi M, Nomura T, Vasilescu A, Kokubo M, Renault V, Hirosawa K, Ratanajaraya C, Heath S, Mimori T, Sakaguchi S, Lathrop M, Melchers I, Kumagai S, Matsuda F. A trans-ethnic genetic study of rheumatoid arthritis identified FCGR2A as a candidate common risk factor in Japanese and European populations. Mod Rheumatol. 2011 May 24. [Epub ahead of print]
  27. ○ Terao C, Ohmura K, Katayama M, Takahashi M, Kokubo M, Diop G, Toda Y, Yamamoto N; Human Disease Genomics Working Group; Rheumatoid Arthritis (RA) Clinical and Genetic Study Consortium, Shinkura R, Shimizu M, Gut I, Heath S, Melchers I, Manabe T, Lathrop M, Mimori T, Yamada R, Matsuda F. Myelin basic protein as a novel genetic risk factor in rheumatoid arthritis–a genome-wide study combined with immunological analyses. PLoS One. 2011; 6: e20457
  28. Arima K, Kinoshita A, Mishima H, Kanazawa N, Kaneko T, Mizushima T, Ichinose K, Nakamura H, Tsujino A, Kawakami A, Matsunaka M, Kasagi S, Kawano S, Kumagai S, Ohmura K, Mimori T, Hirano M, Ueno S, Tanaka K, Tanaka M, Toyoshima I, Sugino H, Yamakawa A, Tanaka K, Niikawa N, Furukawa F, Murata S, Eguchi K, Ida H, Yoshiura K. Proteasome assembly defect due to a proteasome subunit beta type 8 (PSMB8) mutation causes the autoinflammatory disorder, Nakajo-Nishimura syndrome. Proc Natl Acad Sci U S A. 2011; 108: 14914-9.
  29. ○ Terao C, Ohmura K (corresponding author), Kochi Y, Ikari K, Maruya E, Katayama M, Shimada K, Murasawa A, Honjo S, Takasugi K, Matsuo K, Tajima K, Suzuki A, Yamamoto K, Momohara S, Yamanaka H, Yamada R, Saji H, Matsuda F, Mimori T. A large-scale association study identified multiple HLA-DRB1 alleles associated with ACPA-negative rheumatoid arthritis in Japanese subjects. Ann Rheum Dis. 2011; 70: 2134-2139
  30. Terao C, Ohmura K, Yamamoto K, Yukawa N, Kawabata D, Nojima T, Fujii T, Mimori T. Serum IgG levels demonstrate seasonal change in connective tissue diseases: a large-scale, 4-year analysis in Japanese. Mod Rheumatol. 2012 Jun; 22(3):426-30
  31. Iguchi-Hashimoto M, Usui T, Yoshifuji H, Shimizu M, Kobayashi S, Ito Y, Murakami K, Shiomi A, Yukawa N, Kawabata D, Nojima T, Ohmura K, Fujii T, Mimori T. Overexpression of a Minimal Domain of Calpastatin Suppresses IL-6 Production and Th17 Development via Reduced NF-κB and Increased STAT5 Signals. PLoS One. 2011; 6(10): e27020.
  32. Yukawa N, Fujii T, Kondo-Ishikawa S, Yoshifuji H, Kawabata D, Nojima T, Ohmura K, Usui T, Mimori T. Correlation of antinuclear antibody and anti-double-stranded DNA antibody with clinical response to infliximab in patients with rheumatoid arthritis: a retrospective clinical study. Arthritis Res Ther. 2011; 13(6): R213.
  33. Terao C, Ikari K, Ohmura K, Suzuki T, Iwamoto T, Takasugi K, Saji H, Taniguchi A, Momohara S, Yamanaka H, Matsuda F, Mimori T. Quantitative effect of HLA-DRB1 alleles to ACPA levels in Japanese rheumatoid arthritis: no strong genetic impact of shared epitope to ACPA levels after stratification of HLA-DRB1*09:01. Ann Rheum Dis. 2012, 71 (6): 1095-7.
  34. Murakami K, Tanaka M, Usui T, Kawabata D, Shiomi A, Iguchi-Hashimoto M, Shimizu M, Yukawa N, Yoshifuji H, Nojima T, Ohmura K, Fujii T, Umehara H, Mimori T. Follistatin-related protein/follistatin-like 1 evokes an innate immune response via CD14 and toll-like receptor 4. FEBS Lett. 2012 Feb 17; 586(4): 319-24.
  35. Imura Y, Shirai Y, Nojima T, Nakashima R, Yamagata H, Miyachi K, Yoshifuji H, Kawabata D, Ohmura K, Usui T, Fujii T, Mimori T. NEFA/nucleobindin-2 is a target autoantigen of the anti-Wa antibody and is associated with transfer RNA. Mod Rheumatol. 2012 [Epub ahead of print]
  36. Okada Y, Shimane K, Kochi Y, Tahira T, Suzuki A, Higasa K, Takahashi A, Horita T, Atsumi T, Ishii T, Okamoto A, Fujio K, Hirakata M, Amano H, Kondo Y, Ito S, Takada K, Mimori A, Saito K, Kamachi M, Kawaguchi Y, Ikari K, Mohammed OW, Matsuda K, Terao C, Ohmura K, Myouzen K, Hosono N, Tsunoda T, Nishimoto N, Mimori T, Matsuda F, Tanaka Y, Sumida T, Yamanaka H, Takasaki Y, Koike T, Horiuchi T, Hayashi K, Kubo M, Kamatani N, Yamada R, Nakamura Y, Yamamoto K.. A Genome-Wide Association Study Identified AFF1 as a Susceptibility Locus for Systemic Lupus Eyrthematosus in Japanese. PLoS Genet. 2012 Jan;8(1):e1002455.
  37. ○ Okada Y, Terao C, Ikari K, Kochi Y, Ohmura K (corresponding author), Suzuki A, Kawaguchi T, Stahl EA, Kurreeman FA, Nishida N, Ohmiya H, Myouzen K, Takahashi M, Sawada T, Nishioka Y, Yukioka M, Matsubara T, Wakitani S, Teshima R, Tohma S, Takasugi K, Shimada K, Murasawa A, Honjo S, Matsuo K, Tanaka H, Tajima K, Suzuki T, Iwamoto T, Kawamura Y, Tanii H, Okazaki Y, Sasaki T, Gregersen PK, Padyukov L, Worthington J, Siminovitch KA, Lathrop M, Taniguchi A, Takahashi A, Tokunaga K, Kubo M, Nakamura Y, Kamatani N, Mimori T, Plenge RM, Yamanaka H, Momohara S, Yamada R, Matsuda F, Yamamoto K. Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. Nat Genet. 2012, 44(5): 511-6
  38. ○ Terao C, Ohmura K (corresponding author), Ikari K, Kochi Y, Maruya E, Katayama M, Yurugi K, Shimada K, Murasawa A, Honjo S, Takasugi K, Matsuo K, Tajima K, Suzuki A, Yamamoto K, Momohara S, Yamanaka H, Yamada R, Saji H, Matsuda F, Mimori T. ACPA-negative RA consists of two genetically distinct subsets based on RF positivity in Japanese. PLoS One. 2012;7(7): e40067
  39. Kitai Y, Murakami K, Yoshifuji H, Yukawa N, Kawabata D, Ohmura K, Fujii T, Mimori T. A case of Behçet’s disease developing after poststreptococcal acute glomerulonephritis. Mod Rheumatol. 2012 Aug 30. [Epub ahead of print]
  40. Nakano M, Fujii T, Hashimoto M, Yukawa N, Yoshifuji H, Ohmura K, Nakaizumi A, Mimori T. Type I interferon induces CX3CL1 (fractalkine) and CCL5 (RANTES) production in human pulmonary vascular endothelial cells. Clin Exp Immunol. 2012 Oct; 170(1):94-100.
  41. Myouzen K, Kochi Y, Okada Y, Terao C, Suzuki A, Ikari K, Tsunoda T, Takahashi A, Kubo M, Taniguchi A, Matsuda F, Ohmura K, Momohara S, Mimori T, Yamanaka H, Kamatani N, Yamada R, Nakamura Y, Yamamoto K. Functional Variants in NFKBIE and RTKN2 Involved in Activation of the NF-κB Pathway Are Associated with Rheumatoid Arthritis in Japanese. PLoS Genet. 2012 Sep;8(9):e1002949
  42. Kiyama K, Kawabata D, Hosono Y, Kitagori K, Yukawa N, Yoshifuji H, Ohmura K, Fujii T, Mimori T. Serum BAFF and APRIL levels in patients with IgG4-related disease and their clinical significance. Arthritis Res Ther. 2012 Apr 24; 14(2):R86.
  43. Terao C, Ohmura K (corresponding author), Kawaguchi Y, Nishimoto T, Kawasaki A, Takehara K, Furukawa H, Kochi Y, Ota Y, Ikari K, Sato S, Tohma S, Yamada R, Yamamoto K, Kubo M, Yamanaka H, Kuwana M, Tsuchiya N, Matsuda F, Mimori T. PLD4 as a novel susceptibility gene for systemic sclerosis in a Japanese population. Arthritis Rheum. 2013 Feb; 65(2): 472-80.
  44. Terao C, Hashimoto M, Yamamoto K, Murakami K, Ohmura K, Nakashima R, Yamakawa N, Yoshifuji H, Yukawa N, Kawabata D, Usui T, Yoshitomi H, Furu M, Yamada R, Matsuda F, Ito H, Fujii T, Mimori T. Three Groups in the 28 Joints for Rheumatoid Arthritis Synovitis – Analysis Using More than 17,000 Assessments in the KURAMA Database. PLoS One. 2013; 8(3): e59341
  45. Cui J, Stahl EA, Saevarsdottir S, Miceli C, Diogo D, Trynka G, Raj T, Mirkov MU, Canhao H, Ikari K, Terao C, Okada Y, Wedrén S, Askling J, Yamanaka H, Momohara S, Taniguchi A, Ohmura K, Matsuda F, Mimori T, Gupta N, Kuchroo M, Morgan AW, Isaacs JD, Wilson AG, Hyrich KL, Herenius M, Doorenspleet ME, Tak PP, Crusius JB, van der Horst-Bruinsma IE, Wolbink GJ, van Riel PL, van de Laar M, Guchelaar HJ, Shadick NA, Allaart CF, Huizinga TW, Toes RE, Kimberly RP, Bridges SL Jr, Criswell LA, Moreland LW, Fonseca JE, de Vries N, Stranger BE, De Jager PL, Raychaudhuri S, Weinblatt ME, Gregersen PK, Mariette X, Barton A, Padyukov L, Coenen MJ, Karlson EW, Plenge RM. Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid Arthritis. PLoS Genet. 2013 Mar;9(3):e1003394.
  46. ○ Katayama M, Ohmura K (corresponding author), Yukawa N, Terao C, Hashimoto M, Yoshifuji H, Kawabata D, Fujii T, Iwakura Y, Mimori T. Neutrophils are essential as a source of IL-17 in the effector phase of arthritis. PLoS One. 2013 May 6;8(5):e62231
  47. Tsuji H, Yoshifuji H, Nakashima R, Imura Y, Yukawa N, Ohmura K, Miyagawa-Hayashino A, Kabashima K, Mimori T. Sweet’s syndrome associated with systemic lupus erythematosus: a case report and review of the literature. J Dermatol. 2013 Aug;40(8):641-8
  48. Terao C, Yoshifuji H, Kimura A, Matsumura T, Ohmura K, Takahashi M, Shimizu M, Kawaguchi T, Chen Z, Naruse TK, Sato-Otsubo A, Ebana Y, Maejima Y, Kinoshita H, Murakami K, Kawabata D, Wada Y, Narita I, Tazaki J, Kawaguchi Y, Yamanaka H, Yurugi K, Miura Y, Maekawa T, Ogawa S, Komuro I, Nagai R, Yamada R, Tabara Y, Isobe M, Mimori T, Matsuda F. Two susceptibility loci to Takayasu arteritis reveal a synergistic role of the IL12B and HLA-B regions in a Japanese population. Am J Hum Genet. 2013 Aug 8;93(2):289-97
  49. Terao C, Yoshifuji H, Ohmura K, Murakami K, Kawabata D, Yurugi K, Tazaki J, Kinoshita H, Kimura A, Akizuki M, Kawaguchi Y, Yamanaka H, Miura Y, Maekawa T, Saji H, Mimori T, Matsuda F. Association of Takayasu arteritis with HLA-B 67:01 and two amino acids in HLA-B protein. Rheumatology (Oxford). 2013 Oct;52(10):1769-74
  50. Yamakawa N, Fujimoto M, Kawabata D, Terao C, Nishikori M, Nakashima R, Imura Y, Yukawa N, Yoshifuji H, Ohmura K, Fujii T, Kitano T, Kondo T, Yurugi K, Miura Y, Maekawa T, Saji H, Takaori-Kondo A, Matsuda F, Haga H, Mimori T. A Clinical, Pathological, and Genetic Characterization of Methotrexate-associated Lymphoproliferative Disorders. J Rheumatol. 2014 Feb;41(2):293-9
  51. Tanaka K, Terao C, Ohmura K, Takahashi M, Nakashima R, Imura Y, Yoshifuji H, Yukawa N, Usui T, Fujii T, Mimori T, Matsuda F. Significant association between CYP3A5 polymorphism and blood concentration of tacrolimus in patients with connective tissue diseases. J Hum Genet. 2013 Dec 19. [Epub ahead of print]
  52. ○ Okada Y, Wu D, Trynka G, Raj T, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Yoshida S, Graham RR, Manoharan A, Ortmann W, Bhangale T, Denny JC, Carroll RJ, Eyler AE, Greenberg JD, Kremer JM, Pappas DA, Jiang L, Yin J, Ye L, Su DF, Yang J, Xie G, Keystone E, Westra HJ, Esko T, Metspalu A, Zhou X, Gupta N, Mirel D, Stahl EA, Diogo D, Cui J, Liao K, Guo MH, Myouzen K, Kawaguchi T, Coenen MJ, van Riel PL, van de Laar MA, Guchelaar HJ, Huizinga TW, Dieudé P, Mariette X, Louis Bridges Jr S, Zhernakova A, Toes RE, Tak PP, Miceli-Richard C, Bang SY, Lee HS, Martin J, Gonzalez-Gay MA, Rodriguez-Rodriguez L, Rantapää-Dahlqvist S, Arlestig L, Choi HK, Kamatani Y, Galan P, Lathrop M, Eyre S, Bowes J, Barton A, de Vries N, Moreland LW, Criswell LA, Karlson EW, Taniguchi A, Yamada R, Kubo M, Liu JS, Bae SC, Worthington J, Padyukov L, Klareskog L, Gregersen PK, Raychaudhuri S, Stranger BE, De Jager PL, Franke L, Visscher PM, Brown MA, Yamanaka H, Mimori T, Takahashi A, Xu H, Behrens TW, Siminovitch KA, Momohara S, Matsuda F, Yamamoto K, Plenge RM. Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature. 2013 Dec 25. [Epub ahead of print]
  53. Terao C, Hashimoto M, Furu M, Nakabo S, Ohmura K, Nakashima R, Imura Y, Yukawa N, Yoshifuji H, Matsuda F, Ito H, Fujii T, Mimori T. Inverse Association between Air Pressure and Rheumatoid Arthritis Synovitis. PLoS One. 2014 Jan 15;9(1):e85376
  54. Yokoyama T, Fujii T, Kondo-Ishikawa S, Yamakawa N, Nakano M, Yukawa N, Yoshifuji H, Ohmura K, Mimori T. Association between anti-U1 ribonucleoprotein antibodies and inflammatory mediators in cerebrospinal fluid of patients with neuropsychiatric systemic lupus erythematosus. Lupus. 2014 Feb 3. [Epub ahead of print]
  55. ○Yamamoto N, Yamaguchi H, Ohmura K (corresponding author), Yokoyama T, Yoshifuji H, Yukawa N, Kawabata D, Fujii T, Morita S, Nagata S, Mimori T. Serum milk fat globule epidermal growth factor 8 elevation may subdivide systemic lupus erythematosus into two pathophysiologically distinct subsets. Lupus 2014; 23(4): 386-94.
  56. Jin H, Arase N, Hirayasu K, Kohyama M, Suenaga T, Saito F, Tanimura K, Matsuoka S, Ebina K, Shi K, Toyama-Sorimachi N, Yasuda S, Horita T, Hiwa R, Takasugi K, Ohmura K, Yoshikawa H, Saito T, Atsumi T, Sasazuki T, Katayama I, Lanier LL, Arase H. Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility. Proc Natl Acad Sci U S A. 2014; 111(10): 3787-92.
  57. Hashimoto M, Fujii T, Hamaguchi M, Furu M, Ito H, Terao C, Yamamoto K, Yamamoto W, Matsuo T, Mori M, Ohmura K, Kawabata H, Mimori T. Increase of Hemoglobin Levels by Anti-IL-6 Receptor Antibody (Tocilizumab) in Rheumatoid Arthritis. PLoS One. 2014; 9(5): e98202.
  58. Terao C, Ohmura K, Ikari K, Kawaguchi T, Takahashi M, Setoh K, Nakayama T, Kosugi S, Sekine A, Tabara Y, Taniguchi A, Momohara S, Yamanaka H, Yamada R, Matsuda F, Mimori T. Effects of smoking and shared epitope on the production of ACPA and RF in a Japanese adult population: The Nagahama Study. Arthritis Care Res. 2014; 66 (12): 1818-27
  59. Tsuji H, Yoshifuji H, Fujii T, Matsuo T, Nakashima R, Imura Y, Yukawa N, Ohmura K, Sumiyoshi S, Mimori T. Visceral disseminated varicella zoster virus infection after rituximab treatment for granulomatosis with polyangiitis. Mod Rheumatol. 2014; Epub ahead of print
  60. Terao C, Ohmura K, Yamada R, Kawaguchi T, Shimizu M, Tabara Y, Takahashi M, Setoh K, Nakayama T, Kosugi S, Sekine A, Matsuda F, Mimori T; on behalf of the Nagahama Study Group. An association between anti-nuclear antibody and HLA class II locus and heterogeneous characteristics of staining patterns: The Nagahama Study. Arthritis Rheumatol. 2014; 66 (12): 3395-403
  61. Nakajima T, Kawabata D, Nakabo S, Miyagawa-Hayashino A, Yukawa N, Yoshifuji H, Ohmura K, Fujii T, Mimori T. Successful treatment with tocilizumab in a case of intralymphatic histiocytosis associated with rheumatoid arthritis. Intern Med. 2014; 53: 2255-8
  62. Tanimura K, Jin H, Suenaga T, Morikami S, Arase N, Kishida K, Hirayasu K, Kohyama M, Ebina Y, Yasuda S, Horita T, Takasugi K, Ohmura K, Yamamoto K, Katayama I, Sasazuki T, Lanier LL, Atsumi T, Yamada H, Arase H. β2-Glycoprotein I/HLA class II complexes are novel autoantigens in antiphospholipid syndrome. Blood. 2015; 125 (18): 2835-44
  63. Terao C, Yano K, Ikari K, Furu M, Yamakawa N, Yoshida S, Hashimoto M, Ito H, Fujii T, Ohmura K, Yurugi K, Miura Y, Maekawa T, Taniguchi A, Momohara S, Yamanaka H, Mimori T, Matsuda F. A main contribution of DRB1*04:05 among shared epitope and involvement of 57th DRB1 amino acid in association with joint destruction in ACPA(+) RA. Arthritis Rheumatol. 2015 [Epub ahead of print]
  64. Terao C, Asai K, Hashimoto M, Yamazaki T, Ohmura K, Yamaguchi A, Takahashi K, Takei N, Ishii T, Kawaguchi T, Tabara Y, Takahashi M, Nakayama T, Kosugi S, Sekine A, Fujii T, Yamada R, Mimori T, Matsuda F, Bessho K; Nagahama Study Group. Significant association of periodontal disease with anti-citrullinated peptide antibody in a Japanese healthy population – The Nagahama study. J Autoimmun. 2015. Epub 2015
  65. Terao C, Suzuki A, Ikari K, Kochi Y, Ohmura K, Katayama M, Nakabo S, Yamamoto N, Suzuki T, Iwamoto T, Yurugi K, Miura Y, Maekawa T, Takasugi K, Kubo M, Saji H, Taniguchi A, Momohara S, Yamamoto K, Yamanaka H, Mimori T, Matsuda F. An association between the 74th amino acid position of HLA-DRB1 and ACPA levels of Japanese ACPA-positive RA. Arthritis Rheumatol. 2015 Apr 1. doi: 10.1002/art.39133. [Epub ahead of print]
  66. ○ Terao C, Ohmura K (corresponding author), Kochi Y, Ikari K, Okada Y, Shimizu M, Nishina N, Suzuki A, Myouzen K, Kawaguchi T, Takahashi M, Takasugi K, Murasawa A, Mizuki S, Iwahashi M, Funahashi K, Natsumeda M, Furu M, Hashimoto M, Ito H, Fujii T, Ezawa K, Matsubara T, Takeuchi T, Kubo M, Yamada R, Taniguchi A, Yamanaka H, Momohara S, Yamamoto K, Mimori T, Matsuda F. Anti-citrullinated peptide/protein antibody (ACPA)-negative RA shares a large proportion of susceptibility loci with ACPA-positive RA: a meta-analysis of genome-wide association study in a Japanese population. Arthritis Res Ther. 2015; 17 (1): 104
  67. Terao C, Matsumura T, Yoshifuji H, Kirino Y, Maejima Y, Nakaoka Y, Takahashi M, Amiya E, Tamura N, Nakajima T, Origuchi T, Horita T, Matsukura M, Kochi Y, Ogimoto A, Yamamoto M, Takahashi H, Nakayamada S, Saito K, Wada Y, Narita I, Kawaguchi Y, Yamanaka H, Ohmura K, Atsumi T, Tanemoto K, Miyata T, Kuwana M, Komuro I, Tabara Y, Ueda A, Isobe M, Mimori T, Matsuda F. Takayasu arteritis and ulcerative colitis -high concurrence ratio and genetic overlap. Arthritis Rheumatol. 2015 Apr 30. doi: 10.1002/art.39157. [Epub ahead of print]
  68. Kiyama K, Yoshifuji H, Kandou T, Hosono Y, Kitagori K, Nakashima R, Imura Y, Yukawa N, Ohmura K, Fujii T, Kawabata D, Mimori T. Screening for IgG4-type anti-nuclear antibodies in IgG4-related disease. BMC Musculoskelet Disord. 2015; 16 (1): 129.

総説

  • 1) 大村 浩一郎、高杉 潔。関節の診かた(physical examination) Medicina、42巻 758-760 (2005)
  • 2) 大村 浩一郎。 マウス関節炎におけるIL-1bの関与 臨床免疫、45巻 70-74 (2006)
  • 3) 大村 浩一郎、三森 経世。抗シトルリン化蛋白抗体(抗CCP抗体)リウマチ科、36巻 8-15 (2006)

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