笹井 蘭(旧姓 中嶋)

笹井 蘭(旧姓 中嶋)

  • 笹井 蘭(旧姓 中嶋) (ささい らん)
  • 助教
  • 大阪府出身
  • 学位 京都大学医学博士
  • 資格: 日本内科学会総合内科専門医  日本リウマチ学会専門医
  • 学会活動: 日本リウマチ学会評議員  日本臨床免疫学会評議員       日本炎症・再生医学会

ひとこと

  • 患者さんの病気と心に寄り添った診療ができるように努力して参ります。

研究主題

  • 皮膚筋炎・多発性筋炎に伴う間質性肺炎の病態解明

受賞歴

平成22年 KMYIA(平成22年度 京都大学医学部若手研究者優秀論文賞)

平成26年 内科学会奨励賞

略歴

平成14年 京都大学医学部卒業
平成14年 京都大学医学部附属病院内科研修医
平成15年 静岡県立総合病院内科研修医
平成17年 京都大学大学院医学研究科臨床免疫学入学
平成21年 京都大学大学院医学研究科博士課程修了
同上研究生
平成22年 医学博士(京都大学)
京都大学医学部附属病院 
免疫・膠原病内科 医員

平成24年

京都大学医学部附属病院 
免疫・膠原病内科 特定病院助教
 平成28年 京都大学大学院医学研究科 臨床免疫学 助教
現在に至る

代表的な業績 (直近3年)

1: Shirakashi M, Nakashima R, Tsuji H, Tanizawa K, Handa T, Hosono Y, Akizuki S, Murakami K, Hashimoto M, Yoshifuji H, Ohmura K, Mimori T. Efficacy of plasma exchange in anti-MDA5-positive dermatomyositis with interstitial lung disease under combined immunosuppressive treatment. Rheumatology (Oxford). 2020 Apr 10. [Epub ahead of print] 

 

2: Murakami I, Murakami K, Hashimoto M, Tanaka M, Ito H, Fujii T, Torii M, Ikeda K, Kuwabara A, Tanaka K, Yoshida A, Akizuki S, Nakashima R, Yoshifuji H, Ohmura K, Usui T, Morita S, Mimori T. Intake frequency of vegetables or seafoods negatively correlates with disease activity of rheumatoid arthritis. PLoS One. 2020 Feb 13;15(2):e0228852. 

 

3: Minamiyama S, Ueda S, Nakashima R, Yamakado H, Sakato Y, Yamashita H, Sawamoto N, Fujimoto R, Nishino I, Urushitani M, Mimori T, Takahashi R. Thigh muscle MRI findings in myopathy associated with anti-mitochondrial antibody. Muscle Nerve. 2020 Jan;61(1):81-87.

 

4: Tsuji H, Nakashima R, Hosono Y, Imura Y, Yagita M, Yoshifuji H, Hirata S, Nojima T, Sugiyama E, Hatta K, Taguchi Y, Katayama M, Tanizawa K, Handa T, Uozumi R, Akizuki S, Murakami K, Hashimoto M, Tanaka M, Ohmura K, Mimori T. Multicenter Prospective Study of the Efficacy and Safety of Combined Immunosuppressive Therapy With High-Dose Glucocorticoid, Tacrolimus, and Cyclophosphamide in Interstitial Lung Diseases Accompanied by Anti-Melanoma Differentiation-Associated Gene 5-Positive Dermatomyositis. Arthritis Rheumatol.  2020 Mar;72(3):488-498.

 

5: Ishigooka N, Fujii T, Abe H, Murakami K, Nakashima R, Hashimoto M, Yoshifuji H, Tanaka M, Ito H, Ohmura K, Morita S, Mimori T. Predicting factors for disappearance of anti-mutated citrullinated vimentin antibodies in sera of patients with rheumatoid arthritis. Mod Rheumatol. 2020 May;30(3):450-457.

 

6: Nakashima R. Clinical significance of myositis-specific autoantibodies. Immunol Med. 2018 Sep;41(3):103-112.

 

7: Nakatsuka Y, Handa T, Nakashima R, Tanizawa K, Kubo T, Murase Y, Sokai A, Ikezoe K, Hosono Y, Watanabe K, Tokuda S, Uno K, Yoshizawa A, Tsuruyama T, Uozumi R, Nagai S, Hatta K, Taguchi Y, Mishima M, Chin K, Mimori T, Hirai T. Serum matrix metalloproteinase levels in polymyositis/dermatomyositis patients with interstitial lung disease. Rheumatology (Oxford). 2019 Mar 8. [Epub ahead of print] 

 

8: Nakabo S, Ohmura K, Akizuki S, Murakami K, Nakashima R, Hashimoto M, Yoshifuji H, Tanaka M, Mimori T. Activated neutrophil carbamylates albumin via the release of myeloperoxidase and reactive oxygen species regardless of NETosis. Mod Rheumatol. 2020 Mar;30(2):345-349.

 

9: Kitagori K, Yoshifuji H, Oku T, Ayaki T, Kuzuya A, Nakajima T, Akizuki S, Nakashima R, Murakami K, Ohmura K, Hirayama Y, Takahashi R, Mimori T. Utility of osteopontin in cerebrospinal fluid as a diagnostic marker for neuropsychiatric systemic lupus erythematosus. Lupus. 2019 Mar;28(3):414-422.

 

10: Hozumi H, Fujisawa T, Nakashima R, Yasui H, Suzuki Y, Kono M, Karayama M, Furuhashi K, Enomoto N, Inui N, Nakamura Y, Mimori T, Suda T. Efficacy of Glucocorticoids and Calcineurin Inhibitors for Anti-aminoacyl-tRNA Synthetase Antibody-positive Polymyositis/dermatomyositis-associated Interstitial Lung Disease: A Propensity Score-matched Analysis. J Rheumatol. 2019

May;46(5):509-517. 

 

11: Nishioka A, Tsunoda S, Abe T, Yoshikawa T, Takata M, Kitano M, Matsui K, Nakashima R, Hosono Y, Ohmura K, Mimori T, Sano H. Serum neopterin as well as ferritin, soluble interleukin-2 receptor, KL-6 and anti-MDA5 antibody titer provide markers of the response to therapy in patients with interstitial lung disease complicating anti-MDA5 antibody-positive dermatomyositis. Mod Rheumatol. 2019 Sep;29(5):814-820. 

 

12: Nakagawa S, Nakaishi M, Hashimoto M, Ito H, Yamamoto W, Nakashima R, Tanaka M, Fujii T, Omura T, Imai S, Nakagawa T, Yonezawa A, Imai H, Mimori T, Matsubara K. Effect of medication adherence on disease activity among Japanese patients with rheumatoid arthritis. PLoS One. 2018 Nov 2;13(11):e0206943. 

 

13: Takeuchi Y, Hashimoto M, Nakashima R, Tanaka M, Kuramoto N, Murakami K, Yoshifuji H, Ohmura K, Mimori T. Anti-EJ, anti-MDA5 double-positive chronic clinically amyopathic dermatomyositis: a case report. Rheumatol Adv Pract. 2018 Jun 23;2(2):rky022. 

 

14: Tamura M, Kitano M, Azuma K, Tsuboi K, Abe T, Ogita C, Yokoyama Y, Furukawa T, Yoshikawa T, Saito A, Nishioka A, Sekiguchi M, Azuma N, Tsunoda S, Hosono Y, Nakashima R, Ohmura K, Matsui K, Mimori T, Sano H. [A case of anti-PL-7 antibody positive polymyositis with thrombotic microangiopathy]. Nihon Rinsho Meneki Gakkai Kaishi. 2017;40(6):450-455. Japanese

 

15: Kochi Y, Kamatani Y, Kondo Y, Suzuki A, Kawakami E, Hiwa R, Momozawa Y, Fujimoto M, Jinnin M, Tanaka Y, Kanda T, Cooper RG, Chinoy H, Rothwell S, Lamb JA, Vencovský J, Mann H, Ohmura K, Myouzen K, Ishigaki K, Nakashima R, Hosono Y, Tsuboi H, Kawasumi H, Iwasaki Y, Kajiyama H, Horita T, Ogawa-Momohara M, Takamura A, Tsunoda S, Shimizu J, Fujio K, Amano H, Mimori A, Kawakami A, Umehara H, Takeuchi T, Sano H, Muro Y, Atsumi T, Mimura T, Kawaguchi Y, Mimori T, Takahashi A, Kubo M, Kohsaka H, Sumida T, Yamamoto K. Splicing variant of WDFY4 augments MDA5 signalling and the risk of clinically amyopathic dermatomyositis. Ann Rheum Dis. 2018 Apr;77(4):602-611. 

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