Laboratory-based and Translational Research

Dr.Hashimoto’s Labo  [橋本グループ, 日本語ページ]

Basic Research

 

 

 

SKG mice (BALB/c ZAP-70 W163C-mutant)

used as a genetic model of rheumatoid arthritis (RA) or spondyloarthritis (SpA)

 

Under construction

 

B6SKG mice (C57BL/6J ZAP70 skg/skg)

used as a genetic model of systemic lupus erythematosus (SLE)

 

Under construction

 

[Citations]

1) Sakaguchi N, et al. Nature. 2003;426(6965):454-60.

2) Hirota K, Hashimoto M, et al. J Exp Med 2007;204(1):41-7.

3) Hashimoto M, et al. J Exp Med 2010;207(6):1135-43.

4) Ito Y, Hashimoto M, et al. Science 2014;346(6207):363-8.

5) Matsuo T, Hashimoto M, et al. J Immunol 2019;202(11):3161-72.