Dr.Hashimoto’s Labo [橋本グループ, 日本語ページ]
Basic Research
SKG mice (BALB/c ZAP-70 W163C-mutant)
used as a genetic model of rheumatoid arthritis (RA) or spondyloarthritis (SpA)
Under construction
B6SKG mice (C57BL/6J ZAP70 skg/skg)
used as a genetic model of systemic lupus erythematosus (SLE)
Under construction
[Citations]
1) Sakaguchi N, et al. Nature. 2003;426(6965):454-60.
2) Hirota K, Hashimoto M, et al. J Exp Med 2007;204(1):41-7.
3) Hashimoto M, et al. J Exp Med 2010;207(6):1135-43.
4) Ito Y, Hashimoto M, et al. Science 2014;346(6207):363-8.
5) Matsuo T, Hashimoto M, et al. J Immunol 2019;202(11):3161-72.